Chemical allergen-induced perturbations of the mouse lymph node DNA methylome

ABSTRACT: Epigenetic regulation of gene expression plays a pivotal role in the orchestration of immune responses and may determine the vigor, quality, or longevity of such responses. Chemical allergens can be divided into two categories: skin sensitizing chemicals associated with allergic contact dermatitis, and chemicals that cause sensitization of the respiratory tract and occupational asthma. In mice these are characterized by different T helper (Th) cell responses. To explore the regulation and maintenance of these divergent responses, mice were exposed to 2,4-dinitrochlorobenzene (DNCB; a contact allergen) or trimellitic anhydride (TMA; a respiratory allergen). DNA from draining lymph nodes was processed for methylated DNA immunoprecipitation (MeDIP) followed by hybridization to a whole-genome

ORGANISM(S): Mus musculus

SUBMITTER: Arne Mueller 

PROVIDER: E-GEOD-54768 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress