Proteomics

Dataset Information

38

In-depth proteome analysis of FFPE mammary secretory carcinoma specimens


ABSTRACT: Mammary secretory carcinoma (MSC) is one of the rarest types of breast cancer accounting for less than 0.15% of all breast cancers. Traditionally, MSC is considered that it belongs to the phenotypic spectrum of basal-like triple-negative breast carcinoma (BL-TNBC). Here, we present a study of MSC formalin-fixed paraffin embedded (FFPE) tissue specimens using novel in-depth quantitative proteomic strategy.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo sapiens  

TISSUE(S): Breast

DISEASE(S): Breast Secretory Carcinoma

SUBMITTER: Dohyun Han  

LAB HEAD: Dohyun Han

PROVIDER: PXD005303 | Pride | 2018-02-27

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20160420_SC_TMT_6plex_F.msf Msf
20160420_SC_TMT_6plex_F.pep.xml Pepxml
20160420_SC_TMT_6plex_F10_1.raw Raw
20160420_SC_TMT_6plex_F11_1.raw Raw
20160420_SC_TMT_6plex_F12_1.raw Raw
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Publications

Integrated Multi-Omic Analyses Support Distinguishing Secretory Carcinoma of the Breast from Basal-Like Triple-Negative Breast Cancer.

Jin Min-Sun MS   Lee Hyebin H   Woo Jongmin J   Choi Seongmin S   Do Mi Sol MS   Kim Kwangsoo K   Song Min Ji MJ   Kim Youngsoo Y   Park In Ae IA   Han Dohyun D   Ryu Han Suk HS  

Proteomics. Clinical applications 20180330 5


PURPOSE:Secretory carcinoma (SC) of the breast is defined as an indolent tumor but is still categorized into a basal-like triple-negative breast cancer (BL-TNBC) subgroup that generally shows aggressive behavior according to the current classification. Despite the unique clinical behavior of SC, molecular characteristics that reflect biological behaviors of SC remain largely unknown. EXPERIMENTAL DESIGN:A combinatorial approach of whole-exome sequencing and mass spectrometry-based in-depth quant  ...[more]

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