Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
DISEASE(S): Alzheimer Disease
SUBMITTER: Marina Gay
LAB HEAD: Natàlia Carulla
PROVIDER: PXD005657 | Pride | 2021-05-13
REPOSITORIES: Pride
Vázquez de la Torre Aurelio A Gay Marina M Vilaprinyó-Pascual Sílvia S Mazzucato Roberta R Serra-Batiste Montserrat M Vilaseca Marta M Carulla Natàlia N
Analytical chemistry 20180323 7
Brain-derived amyloid-β (Aβ) dimers are associated with Alzheimer's disease (AD). However, their covalent nature remains controversial. This feature is relevant, as a covalent cross-link has been proposed to make brain-derived dimers (brain dimers) more synaptotoxic than Aβ monomers and would also make them suitable candidates for biomarker development. To resolve this controversy, we here present a three-step approach. First, we validated a type of synthetic cross-linked Aβ (CL Aβ) dimers, obta ...[more]