Proteomics

Dataset Information

38

The Proteomic Fingerprint of Prostate Cancer in Primary Tumors and Recurrent Lymph Node Metastases


ABSTRACT: We performed a quantitative proteome comparison on formalin-fixed paraffin embedded (FFPE) tissue of metastasized and non-metastasized primary prostate cancer (PCa) and on recurrent lymph node metastases. Comparing these three sample groups, we aimed to identify proteins, that might potentially promote/supress tumor progression or metastasis formation. Proteins were quantified label-free. Proteins with interesting biological functions were followed-up by immunohistochemistry.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo sapiens  

TISSUE(S): Prostate Gland, Lymph Node

DISEASE(S): Prostate Adenocarcinoma

SUBMITTER: Ann-Kathrin Müller  

LAB HEAD: Oliver Schilling

PROVIDER: PXD005833 | Pride | 2017-12-19

REPOSITORIES: Pride

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Publications

Proteomic Characterization of Prostate Cancer to Distinguish Nonmetastasizing and Metastasizing Primary Tumors and Lymph Node Metastases.

Müller Ann-Kathrin AK   Föll Melanie M   Heckelmann Bianca B   Kiefer Selina S   Werner Martin M   Schilling Oliver O   Biniossek Martin L ML   Jilg Cordula Annette CA   Drendel Vanessa V  

Neoplasia (New York, N.Y.) 20171214 2


Patients with metastatic prostate cancer (PCa) have a poorer prognosis than patients with organ-confined tumors. We strove to uncover the proteome signature of primary PCa and associated lymph node metastases (LNMs) in order to identify proteins that may indicate or potentially promote metastases formation. We performed a proteomic comparative profiling of PCa tissue from radical prostatectomy (RPE) of patients without nodal metastases or relapse at the time of surgical resection (n=5) to PCa ti  ...[more]

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