Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Tamar Geiger
LAB HEAD: Tamar Geiger
PROVIDER: PXD005913 | Pride | 2017-11-30
REPOSITORIES: Pride
Gavish-Izakson Michal M Velpula Bhagya Bhavana BB Elkon Ran R Prados-Carvajal Rosario R Barnabas Georgina D GD Ugalde Alejandro Pineiro AP Agami Reuven R Geiger Tamar T Huertas Pablo P Ziv Yael Y Shiloh Yosef Y
Nucleic acids research 20180101 2
The DNA damage response (DDR) is an extensive signaling network that is robustly mobilized by DNA double-strand breaks (DSBs). The primary transducer of the DSB response is the protein kinase, ataxia-telangiectasia, mutated (ATM). Here, we establish nuclear poly(A)-binding protein 1 (PABPN1) as a novel target of ATM and a crucial player in the DSB response. PABPN1 usually functions in regulation of RNA processing and stability. We establish that PABPN1 is recruited to the DDR as a critical regul ...[more]