Proteomics

Dataset Information

0

HIV-Tat treatment of human neurons in vitro over time: towards a model for the molecular pathology of HIV-associated neurocognitive disorders (~90% cell culture confluence dataset)


ABSTRACT: We have used LC-MSMS discovery proteomics to identify the quantitative, cell-wide changes that occur when non-transformed, differentiated human neurons are treated with HIV-Tat over time. This may represent a novel cell culture model for initial HIV-associated neurocognitive disorder progression.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo sapiens  

TISSUE(S): Cell Culture, Neural Stem Cell

DISEASE(S): Human Immunodeficiency Virus Infectious Disease

SUBMITTER: Kim Gurwitz  

LAB HEAD: Prof. Jonathan Blackburn

PROVIDER: PXD006314 | Pride | 2017-05-19

REPOSITORIES: pride

altmetric image

Publications

Time-Dependent, HIV-Tat-Induced Perturbation of Human Neurons In Vitro: Towards a Model for the Molecular Pathology of HIV-Associated Neurocognitive Disorders.

Gurwitz Kim T KT   Burman Richard J RJ   Murugan Brandon D BD   Garnett Shaun S   Ganief Tariq T   Soares Nelson C NC   Raimondo Joseph V JV   Blackburn Jonathan M JM  

Frontiers in molecular neuroscience 20170529


A significant proportion of human immunodeficiency virus type 1 (HIV)-positive individuals are affected by the cognitive, motor and behavioral dysfunction that characterizes HIV-associated neurocognitive disorders (HAND). While the molecular etiology of HAND remains largely uncharacterized, HIV transactivator of transcription (HIV-Tat) is thought to be an important etiological cause. Here we have used mass spectrometry (MS)-based discovery proteomics to identify the quantitative, cell-wide chang  ...[more]

Similar Datasets

2017-05-19 | PXD006332 | Pride
2015-09-10 | PXD002150 | Pride
2014-03-05 | E-GEOD-50834 | ArrayExpress
2013-07-10 | E-GEOD-43746 | ArrayExpress
2014-03-05 | E-GEOD-50835 | ArrayExpress
2009-01-01 | E-MEXP-1904 | ArrayExpress
2020-02-14 | PXD011079 | Pride
2020-04-17 | PXD018271 | Pride
2014-02-20 | E-GEOD-52791 | ArrayExpress
2011-09-24 | E-GEOD-28160 | ArrayExpress