Mass spectrometry-based quantification of the cellular response to ultraviolet radiation in HeLa cells
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ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: 
zhou lianqi
LAB HEAD: Yuejin Hua
PROVIDER: PXD006518 | Pride | 2018-04-05
REPOSITORIES: Pride
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Publications
Mass spectrometry-based quantification of the cellular response to ultraviolet radiation in HeLa cells.
Xu Hong H Chen Xuanyi X Ying Nanjiao N Wang Meixia M Xu Xiaoli X Shi Rongyi R Hua Yuejin Y
PloS one 20171120 11
Ultraviolet (UV) irradiation is a common form of DNA damage that can cause pyrimidine dimers between DNA, which can cause gene mutations, even double-strand breaks and threaten genome stability. If DNA repair systems default their roles at this stage, the organism can be damaged and result in disease, especially cancer. To better understand the cellular response to this form of damage, we applied highly sensitive mass spectrometry to perform comparative proteomics of phosphorylation in HeLa cell ...[more]
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