Phosphoproteome analysis of bone marrow-derived dendritic cells infected by Francisella tularensis – proteome dataset

ABSTRACT: Francisella tularensis is a highly infective Gram-negative bacterium, also known as the causative agent of tularemia. The disease is characterized by the delayed onset of the adaptive immune response which provides time for the bacterial replication. As an intracellular pathogen, Francisella proliferates mainly in the cytosol of host phagocytes, which are linkers between the innate and the adaptive immunity. In particular, dendritic cells (DCs) are known to be the most effective antigen-presenting cells and thus they are crucial for the induction of the adaptive response. However, Francisella is able to invade and to proliferate inside DCs while avoiding their effective activation and maturation. The uploaded dataset relates to phosphoproteome analysis of DCs infected by virulent and attenuated Francisella strains (dataset identifier PXD005747) and provides data of DC proteome changes at 60 min p.i.

INSTRUMENT(S):

ORGANISM(S): Francisella Tularensis Subsp. Holarctica Fsc200 Mus Musculus (mouse)

TISSUE(S): Dendritic Cell, Cell Culture, Bone Marrow

DISEASE(S): Tularemia

SUBMITTER: Ivo Fabrik  

LAB HEAD: Jiri Stulik

PROVIDER: PXD006759 | Pride | 2017-10-26

REPOSITORIES: Pride