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The effects of spaceflight on the muscles of the murine shoulder

ABSTRACT: The study compared the protein composition of supraspinatus muscle from the spaceflight mice subjected to either the 13-day NASA STS-135 mission or the 30-day Bion-M1 mission and their corresponding ground control mice.

INSTRUMENT(S): LTQ Orbitrap, LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Skeletal Muscle

SUBMITTER: James Malone

LAB HEAD: James Malone

PROVIDER: PXD006764 | Pride | 2019-11-08

REPOSITORIES: Pride

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Effects of spaceflight on the muscles of the murine shoulder.

Shen Hua H Lim Chanteak C Schwartz Andrea G AG Andreev-Andrievskiy Alexander A Deymier Alix C AC Thomopoulos Stavros S

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20170817 12

Mechanical loading is necessary for the development and maintenance of the musculoskeletal system. Removal of loading <i>via</i> microgravity, paralysis, or bed rest leads to rapid loss of muscle mass and function; however, the molecular mechanisms that lead to these changes are largely unknown, particularly for the spaceflight (SF) microgravity environment. Furthermore, few studies have explored these effects on the shoulder, a dynamically stabilized joint with a large range of motion; therefor ...[more]

PMID: 28821629

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