Mass spec analysis of primary human erythroid cultures (healthy or thalassemic and treated or untreated with Decitabine)

ABSTRACT: Reactivation of gamma-globin is considered a promising approach for the treatment of beta-thalassaemia and sickle cell disease. Therapeutic induction of gamma-globin expression is fraught with lack of suitable therapeutic targets. In order to identify new potential targets we analysed the changes in the proteome of human primary erythroid progenitor cells by treatment with decitabine, a known, yet not clinically safe, gamma-globin inducer. Significant differentially expressed proteins were identified which were involved in various biological pathways and functional categories.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Cell Culture

DISEASE(S): Thalassemia

SUBMITTER: Eleni Katsantoni  

LAB HEAD: Eleni Katsantoni

PROVIDER: PXD006889 | Pride | 2020-01-23

REPOSITORIES: Pride