Human Mitochondrial NFS1-FXN XL LS-MS/MS

ABSTRACT: Frataxin (FXN) is involved in mitochondrial iron-sulfur (Fe-S) cluster biogenesis and serves to accelerate Fe-S cluster formation. FXN deficiency is associated with Friedreich ataxia, a neurodegenerative disease. Using chemical cross-linking (XL) accompanied with LC-MS/MS, we studied the the interaction between the core complexes Acp-ISD11-NFS1 (AIN) and AIN-ISCU (AINU) with FXN.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell

DISEASE(S): Friedreich Ataxia

SUBMITTER: Kai Cai  

LAB HEAD: John L. Markley

PROVIDER: PXD006928 | Pride | 2018-07-11

REPOSITORIES: Pride