Dataset Information


Mouse CD4+ T cells IP-MS

ABSTRACT: Identifying Smad4-binding proteins in mouse CD4+ T cells under IL6SB condition. Mouse CD4+ T cells were isolated from mouse spleen and lymph nodes.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus musculus  

TISSUE(S): Spleen, Lymph Node

DISEASE(S): Not Available

SUBMITTER: Yisong Wan  

LAB HEAD: Yisong Wan

PROVIDER: PXD007172 | Pride | 2017-10-26


altmetric image


T helper 17 (TH17) cells are critically involved in host defence, inflammation, and autoimmunity. Transforming growth factor β (TGFβ) is instrumental in TH17 cell differentiation by cooperating with interleukin-6 (refs 6, 7). Yet, the mechanism by which TGFβ enables TH17 cell differentiation remains elusive. Here we reveal that TGFβ enables TH17 cell differentiation by reversing SKI-SMAD4-mediated suppression of the expression of the retinoic acid receptor (RAR)-related orphan receptor γt (RORγt  ...[more]

Similar Datasets

2018-10-25 | PXD003210 | Pride
2017-05-30 | PXD006459 | Pride
2015-05-26 | PXD002104 | Pride
2013-11-01 | E-GEOD-50921 | ArrayExpress
2015-12-07 | PXD002944 | Pride
2015-04-19 | E-GEOD-67941 | ArrayExpress
2015-05-19 | E-GEOD-60584 | ArrayExpress
2016-01-15 | E-GEOD-72574 | ArrayExpress
2016-03-15 | E-GEOD-76391 | ArrayExpress
2016-04-01 | E-GEOD-79243 | ArrayExpress