Proteomics

Dataset Information

167

Mouse CD4+ T cells IP-MS


ABSTRACT: Identifying Smad4-binding proteins in mouse CD4+ T cells under IL6SB condition. Mouse CD4+ T cells were isolated from mouse spleen and lymph nodes.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus musculus  

TISSUE(S): Spleen, Lymph Node

DISEASE(S): Not Available

SUBMITTER: Yisong Wan  

LAB HEAD: Yisong Wan

PROVIDER: PXD007172 | Pride | 2017-10-26

REPOSITORIES: Pride

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Publications


T helper 17 (TH17) cells are critically involved in host defence, inflammation, and autoimmunity. Transforming growth factor β (TGFβ) is instrumental in TH17 cell differentiation by cooperating with interleukin-6 (refs 6, 7). Yet, the mechanism by which TGFβ enables TH17 cell differentiation remains elusive. Here we reveal that TGFβ enables TH17 cell differentiation by reversing SKI-SMAD4-mediated suppression of the expression of the retinoic acid receptor (RAR)-related orphan receptor γt (RORγt  ...[more]

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