Quantifying extracellular matrix turnover in human lung scaffold cultures
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Lung, Cell Culture, Fibroblast
SUBMITTER: 
Oskar Rosmark
LAB HEAD: Gunilla Westergren-Thorsson
PROVIDER: PXD007995 | Pride | 2018-04-09
REPOSITORIES: Pride
Publications
Quantifying extracellular matrix turnover in human lung scaffold cultures.
Rosmark Oskar O Åhrman Emma E Müller Catharina C Elowsson Rendin Linda L Eriksson Leif L Malmström Anders A Hallgren Oskar O Larsson-Callerfelt Anna-Karin AK Westergren-Thorsson Gunilla G Malmström Johan J
Scientific reports 20180403 1
Remodelling of the extracellular matrix is accomplished by altering the balance between matrix macromolecule production and degradation. However, it is not well understood how cells balance production of new matrix molecules and degradation of existing ones during tissue remodelling and regeneration. In this study, we used decellularized lung scaffolds repopulated with allogenic lung fibroblasts cultured with stable isotope labelled amino acids to quantify the balance between matrix production a ...[more]
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