Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Ovarian Surface Epithelial Cell, Ascites, Macrophage
DISEASE(S): Ovary Serous Adenocarcinoma
SUBMITTER: Florian Finkernagel
LAB HEAD: Rolf Mueller
PROVIDER: PXD008047 | Pride | 2017-11-17
REPOSITORIES: Pride
Worzfeld Thomas T Finkernagel Florian F Reinartz Silke S Konzer Anne A Adhikary Till T Nist Andrea A Stiewe Thorsten T Wagner Uwe U Looso Mario M Graumann Johannes J Müller Rolf R
Molecular & cellular proteomics : MCP 20171115 2
Ovarian cancer is characterized by early transcoelomic metastatic spread via the peritoneal fluid, where tumor cell spheroids (TU), tumor-associated T cells (TAT), and macrophages (TAM) create a unique microenvironment promoting cancer progression, chemoresistance, and immunosuppression. However, the underlying signaling mechanisms remain largely obscure. To chart these signaling networks, we performed comprehensive proteomic and transcriptomic analyses of TU, TAT, and TAM from ascites of ovaria ...[more]