Dataset Information


Human brain LC-MS/MS - Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4+ T Cells in Multiple Sclerosis

ABSTRACT: Citrullination as a post-translational modification has been described in a couple of autoimmune diseases like rheumatoid arthritis (RA) and multiples sclerosis (MS). We investigated citrullination brain tissue from MS patients and healthy individuals (HD). The myelin sheath proteins have been the focus of citrullination and neurodegenerative diseases like Alzheimers Disease (AD), Parkinsons and MS. We analysed whole brain tissue of MS patients and HD and established a catalogue of citrullinated proteins. Besides new citrullinated proteins we found additional citrullinated sites on the already described proteins: MBP, GFAP and Vimentin.


ORGANISM(S): Homo sapiens  

TISSUE(S): Brain

DISEASE(S): Multiple Sclerosis

SUBMITTER: Wolfgang Faigle  

LAB HEAD: Prof. Dr. Roland Martin

PROVIDER: PXD008344 | Pride | 2019-04-10


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20160312_02_A1.mgf Mgf
20160312_02_A1.raw Raw
20160312_03_A2.mgf Mgf
20160312_03_A2.raw Raw
20160312_04_A3.mgf Mgf
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Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4<sup>+</sup> T Cells in Multiple Sclerosis.

Faigle Wolfgang W   Cruciani Carolina C   Wolski Witold W   Roschitzki Bernd B   Puthenparampil Marco M   Tomas-Ojer Paula P   Sellés-Moreno Carla C   Zeis Thomas T   Jelcic Ivan I   Schaeren-Wiemers Nicole N   Sospedra Mireia M   Martin Roland R  

Frontiers in immunology 20190410

Immune responses to citrullinated peptides have been described in autoimmune diseases like rheumatoid arthritis (RA) and multiple sclerosis (MS). We investigated the post-translational modification (PTM), arginine to citrulline, in brain tissue of MS patients and controls (C) by proteomics and subsequently the cellular immune response of cerebrospinal fluid (CSF)-infiltrating T cells to citrullinated and unmodified peptides of myelin basic protein (MBP). Using specifically adapted tissue extract  ...[more]

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