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Differential quantitative proteome analysis of cerebellar flocculus on oculomotor behavior training mouse model

ABSTRACT: Oculomotor behavior model system is commonly employed to study the neural circuits and the cellular mechanisms underlying neural integration related to motor behavior. The flocculus is a small lobe at the posterior border of the middle cerebellar and involved in motor control to aid in the oculomotor system in the brain. However, only several studies have investigated the molecular mechanism of learning and memory in flocculus region using another approach than proteomics.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain, Granule Cell, Purkinje Cell

SUBMITTER: Jongmin Woo

LAB HEAD: Youngsoo Kim

PROVIDER: PXD008433 | Pride | 2020-03-20

REPOSITORIES: Pride

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Quantitative Proteomics Reveals Distinct Molecular Signatures of Different Cerebellum-Dependent Learning Paradigms.

Kim Yong Gyu YG Woo Jongmin J Park Joonho J Kim Sooyong S Lee Yong-Seok YS Kim Youngsoo Y Kim Sang Jeong SJ

Journal of proteome research 20200330 5

The cerebellum improves motor performance by adjusting motor gain appropriately. As de novo protein synthesis is essential for the formation and retention of memories, we hypothesized that motor learning in the opposite direction would induce a distinct pattern of protein expression in the cerebellum. We conducted quantitative proteomic profiling to compare the level of protein expression in the cerebellum at 1 and 24 h after training from mice that underwent different paradigms of cerebellum-de ...[more]

PMID: 32181667

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