Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brown Adipose Tissue
SUBMITTER: Danielle Swaney
LAB HEAD: Danielle Swaney
PROVIDER: PXD008599 | Pride | 2018-07-12
REPOSITORIES: Pride
Masand Ruchi R Paulo Esther E Wu Dongmei D Wang Yangmeng Y Swaney Danielle L DL Jimenez-Morales David D Krogan Nevan J NJ Wang Biao B
Cell metabolism 20180301 3
Brown adipose tissue (BAT) thermogenesis is critical for thermoregulation and contributes to total energy expenditure. However, whether BAT has non-thermogenic functions is largely unknown. Here, we describe that BAT-specific liver kinase b1 knockout (Lkb1<sup>BKO</sup>) mice exhibited impaired BAT mitochondrial respiration and thermogenesis but reduced adiposity and liver triglyceride accumulation under high-fat-diet feeding at room temperature. Importantly, these metabolic benefits were also p ...[more]