Proteomics

Dataset Information

42

Immunoaffinity enrichemt of GREB1 to co-enrich HSP90


ABSTRACT: Immunoaffinity enrichemt of GREB1 to co-enrich HSP90

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo sapiens  

TISSUE(S): Tissue Not Applicable To Dataset

DISEASE(S): Not Available

SUBMITTER: Maria Faelth Savitski  

LAB HEAD: Marcus Bantscheff

PROVIDER: PXD008631 | Pride | 2018-05-02

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
05921_F1_R1_P0181863A01_TMT10.raw.gz Raw
05921_F1_R1_P0181863A03_TMT10.raw.gz Raw
F354476.dat Other
F354493.dat Other
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Publications


Protein degradation plays important roles in biological processes and is tightly regulated. Further, targeted proteolysis is an emerging research tool and therapeutic strategy. However, proteome-wide technologies to investigate the causes and consequences of protein degradation in biological systems are lacking. We developed "multiplexed proteome dynamics profiling" (mPDP), a mass-spectrometry-based approach combining dynamic-SILAC labeling with isobaric mass tagging for multiplexed analysis of  ...[more]

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