Proteomics

Dataset Information

50

Survival and pleurodesis response markers in malignant pleural effusion – The PROMISE study


ABSTRACT: Background: Malignant pleural effusion (MPE) is a common condition that indicates advanced malignancy, incurability and short life expectancy. While MPE incidence is increasing worldwide, prognostic biomarkers to plan treatment and to understand the underlying mechanisms of disease progression remain unidentified. Objective: To discover, validate, and prospectively assess biomarkers of survival and pleurodesis response in MPE. To combine clinical, radiologic, and pleural fluid biologic parameters in order to build a score that forecasts survival. Conclusions: The PROMISE score is the first prospectively validated prognostic model for MPE that combines biological and clinical parameters to accurately estimate 3-month mortality.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo sapiens  

TISSUE(S): Lung

DISEASE(S): Not Available

SUBMITTER: Philip Charles  

LAB HEAD: Ioannis Psallidas

PROVIDER: PXD008682 | Pride | 2018-07-17

REPOSITORIES: Pride

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<h4>Background</h4>The prevalence of malignant pleural effusion is increasing worldwide, but prognostic biomarkers to plan treatment and to understand the underlying mechanisms of disease progression remain unidentified. The PROMISE study was designed with the objectives to discover, validate, and prospectively assess biomarkers of survival and pleurodesis response in malignant pleural effusion and build a score that predicts survival.<h4>Methods</h4>In this multicohort study, we used five separ  ...[more]

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