Proteomics

Dataset Information

30

Saccharomyces cerevisiae mitochondrial fractions by LC-MS/MS


ABSTRACT: Investigation into the role of the Saccharomyces cerevisiae ATP-dependent RNA helicase MSS116 in mitochondrial splicing.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Saccharomyces cerevisiae  

TISSUE(S): Tissue Not Applicable To Dataset

DISEASE(S): Not Available

SUBMITTER: Holger Kramer  

LAB HEAD: Tobias Warnecke

PROVIDER: PXD008785 | Pride | 2018-04-09

REPOSITORIES: Pride

altmetric image

Publications

Normal mitochondrial function in Saccharomyces cerevisiae has become dependent on inefficient splicing.

Rudan Marina M   Bou Dib Peter P   Musa Marina M   Kanunnikau Matea M   Sobočanec Sandra S   Rueda David D   Warnecke Tobias T   Kriško Anita A  

eLife 20180323


Self-splicing introns are mobile elements that have invaded a number of highly conserved genes in prokaryotic and organellar genomes. Here, we show that deletion of these selfish elements from the Saccharomyces cerevisiae mitochondrial genome is stressful to the host. A strain without mitochondrial introns displays hallmarks of the retrograde response, with altered mitochondrial morphology, gene expression and metabolism impacting growth and lifespan. Deletion of the complete suite of mitochondr  ...[more]

Similar Datasets

2019-03-13 | PXD012535 | Pride
2019-06-14 | PXD012241 | Pride
2008-12-11 | E-GEOD-13217 | ArrayExpress
2019-02-13 | PXD010603 | Pride
2018-12-17 | PXD010672 | Pride
2011-07-21 | E-GEOD-29646 | ArrayExpress
2019-02-12 | PXD011923 | Pride
2018-01-30 | E-MTAB-5582 | ArrayExpress
2017-01-04 | PXD005337 | Pride
2012-03-08 | E-GEOD-35339 | ArrayExpress