Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Holger Kramer
LAB HEAD: Tobias Warnecke
PROVIDER: PXD008785 | Pride | 2018-04-09
REPOSITORIES: Pride
Rudan Marina M Bou Dib Peter P Musa Marina M Kanunnikau Matea M Sobočanec Sandra S Rueda David D Warnecke Tobias T Kriško Anita A
eLife 20180323
Self-splicing introns are mobile elements that have invaded a number of highly conserved genes in prokaryotic and organellar genomes. Here, we show that deletion of these selfish elements from the <i>Saccharomyces cerevisiae</i> mitochondrial genome is stressful to the host. A strain without mitochondrial introns displays hallmarks of the retrograde response, with altered mitochondrial morphology, gene expression and metabolism impacting growth and lifespan. Deletion of the complete suite of mit ...[more]