Dataset Information


Saccharomyces cerevisiae mitochondrial fractions by LC-MS/MS

ABSTRACT: Investigation into the role of the Saccharomyces cerevisiae ATP-dependent RNA helicase MSS116 in mitochondrial splicing.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Saccharomyces cerevisiae  

TISSUE(S): Tissue Not Applicable To Dataset

DISEASE(S): Not Available

SUBMITTER: Holger Kramer  

LAB HEAD: Tobias Warnecke

PROVIDER: PXD008785 | Pride | 2018-04-09


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Normal mitochondrial function in Saccharomyces cerevisiae has become dependent on inefficient splicing.

Rudan Marina M   Bou Dib Peter P   Musa Marina M   Kanunnikau Matea M   Sobočanec Sandra S   Rueda David D   Warnecke Tobias T   Kriško Anita A  

eLife 20180323

Self-splicing introns are mobile elements that have invaded a number of highly conserved genes in prokaryotic and organellar genomes. Here, we show that deletion of these selfish elements from the Saccharomyces cerevisiae mitochondrial genome is stressful to the host. A strain without mitochondrial introns displays hallmarks of the retrograde response, with altered mitochondrial morphology, gene expression and metabolism impacting growth and lifespan. Deletion of the complete suite of mitochondr  ...[more]

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