Proteomics

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Application of Multiplexed Ion Mobility Spectrometry towards the Identification of Host Protein Signatures of Treatment Effect in Pulmonary Tuberculosis

ABSTRACT: Utilized sensitive, high throughput multiplexed ion mobility-mass spectrometry (IM-MS) to characterize the serum proteome of tuberculosis patients prior to and at 8 weeks of antibiotic treatment. Goal is to identify a serum protein signature indicative of treatment effect.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

DISEASE(S): Pulmonary Tuberculosis

SUBMITTER: Matthew Monroe  

LAB HEAD: Payam Nahid

PROVIDER: PXD009029 | Pride | 2018-10-19

REPOSITORIES: Pride

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Application of multiplexed ion mobility spectrometry towards the identification of host protein signatures of treatment effect in pulmonary tuberculosis.

Kedia Komal K   Wendler Jason P JP   Baker Erin S ES   Burnum-Johnson Kristin E KE   Jarsberg Leah G LG   Stratton Kelly G KG   Wright Aaron T AT   Piehowski Paul D PD   Gritsenko Marina A MA   Lewinsohn David M DM   Sigal George B GB   Weiner Marc H MH   Smith Richard D RD   Jacobs Jon M JM   Nahid Payam P  

Tuberculosis (Edinburgh, Scotland) 20180718

<h4>Rationale</h4>The monitoring of TB treatments in clinical practice and clinical trials relies on traditional sputum-based culture status indicators at specific time points. Accurate, predictive, blood-based protein markers would provide a simpler and more informative view of patient health and response to treatment.<h4>Objective</h4>We utilized sensitive, high throughput multiplexed ion mobility-mass spectrometry (IM-MS) to characterize the serum proteome of TB patients at the start of and a  ...[more]

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