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Oral Pathogen ‘Neutralizes’ the Human Innate Immune Defence

ABSTRACT: Our present findings show for the first time that the virulence factor PPAD protects the oral pathogen P. gingivalis against neutrophil insults at three distinct levels, namely phagocytosis, NETosis and CAMP activity. This identifies PPAD as a major agent in the evasion of human innate immunity, a view that is supported by studies from Potempa and co-workers showing PPAD-dependent citrullination of complement.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Porphyromonas Gingivalis (strain Atcc Baa-308 / W83)

SUBMITTER: Thomas Sura

LAB HEAD: Dörte Becher

PROVIDER: PXD009081 | Pride | 2018-10-15

REPOSITORIES: Pride

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The Extracellular Proteome and Citrullinome of the Oral Pathogen Porphyromonas gingivalis

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