Proteomics

Dataset Information

0

Klebsiella pneumoniae protomic response to antibiotics


ABSTRACT: Bacteria can circumvent the effect of antibiotics by transitioning to a poorly understood physiological state that does not involve conventional genetic elements of resistance. Here we examine antibiotic susceptibility with a Class A β-lactamase+ invasive strain of Klebsiella pneumoniae that was isolated from a lethal outbreak within laboratory colonies of Chlorocebus aethiops sabaeus monkeys. Bacterial responses to the ribosomal synthesis inhibitors streptomycin and doxycycline resulted in distinct proteomic adjustments that facilitated decreased susceptibility to each antibiotic.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Klebsiella pneumoniae  

TISSUE(S): Tissue Not Applicable To Dataset

DISEASE(S): Not Available

SUBMITTER: Moo-Jin Suh  

LAB HEAD: Moojin Suh

PROVIDER: PXD009175 | Pride | 2019-03-14

REPOSITORIES: Pride

altmetric image

Publications

Decreased Antibiotic Susceptibility Driven by Global Remodeling of the Klebsiella pneumoniae Proteome.

Keasey Sarah L SL   Suh Moo-Jin MJ   Suh Moo-Jin MJ   Das Sudipto S   Blancett Candace D CD   Zeng Xiankun X   Andresson Thorkell T   Sun Mei G MG   Ulrich Robert G RG  

Molecular & cellular proteomics : MCP 20190107 4


Bacteria can circumvent the effect of antibiotics by transitioning to a poorly understood physiological state that does not involve conventional genetic elements of resistance. Here we examine antibiotic susceptibility with a Class A β-lactamase+ invasive strain of Klebsiella pneumoniae that was isolated from a lethal outbreak within laboratory colonies of Chlorocebus aethiops sabaeus monkeys. Bacterial responses to the ribosomal synthesis inhibitors streptomycin and doxycycline resulted in dist  ...[more]

Similar Datasets

2019-03-14 | PXD010244 | Pride
2014-04-02 | E-GEOD-56133 | ArrayExpress
2014-06-04 | E-GEOD-58213 | ArrayExpress
2009-09-01 | GSE12779 | GEO
2009-09-01 | E-GEOD-12779 | ArrayExpress
2012-07-01 | GSE38880 | GEO
| GSE80251 | GEO
2012-06-30 | E-GEOD-38880 | ArrayExpress
2015-01-26 | E-GEOD-60568 | ArrayExpress
| GSE65558 | GEO