H4K20me2 SILAC Nucleosome Affinity Purification
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hela Cell
SUBMITTER: 
Saulius Lukauskas
LAB HEAD: Till Bartke
PROVIDER: PXD009281 | Pride | 2019-02-27
REPOSITORIES: Pride
Publications
H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.
Nakamura Kyosuke K Saredi Giulia G Becker Jordan R JR Foster Benjamin M BM Nguyen Nhuong V NV Beyer Tracey E TE Cesa Laura C LC Faull Peter A PA Lukauskas Saulius S Frimurer Thomas T Chapman J Ross JR Bartke Till T Groth Anja A
Nature cell biology 20190225 3
Genotoxic DNA double-strand breaks (DSBs) can be repaired by error-free homologous recombination (HR) or mutagenic non-homologous end-joining<sup>1</sup>. HR supresses tumorigenesis<sup>1</sup>, but is restricted to the S and G2 phases of the cell cycle when a sister chromatid is present<sup>2</sup>. Breast cancer type 1 susceptibility protein (BRCA1) promotes HR by antagonizing the anti-resection factor TP53-binding protein 1(53BP1) (refs. <sup>2-5</sup>), but it remains unknown how BRCA1 funct ...[more]
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