D2Ome - rate constant estimation from heavy water metabolic labeling and LC-MS

ABSTRACT: We developed a software for extraction of protein decay rate constants from heavy water labeling followed by LC-MS experiments. We illustrate the program on application to normal diet and western diet fed LDLR-/- mice. We demonstrate that proteins subunits of 40S ribosomal complex have reduced stability in western diet fet mice.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Ahmad Borzoo  

LAB HEAD: Rovshan G. Sadygov

PROVIDER: PXD009493 | Pride | 2019-04-10

REPOSITORIES: Pride