Human brain Alzheimer's - Proteomic signatures of brain regions affected by tau pathology in early and late stages of Alzheimer's disease
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
DISEASE(S): Alzheimer's Disease
SUBMITTER: 
Melinda Rezeli
LAB HEAD: Gyögy Marko-Varga
PROVIDER: PXD010138 | Pride | 2019-07-01
REPOSITORIES: Pride
Publications
Proteomic signatures of brain regions affected by tau pathology in early and late stages of Alzheimer's disease.
Mendonça Clarissa Ferolla CF Kuras Magdalena M Nogueira Fábio César Sousa FCS Plá Indira I Hortobágyi Tibor T Csiba László L Palkovits Miklós M Renner Éva É Döme Péter P Marko-Varga György G Domont Gilberto B GB Rezeli Melinda M
Neurobiology of disease 20190615
<h4>Background</h4>Alzheimer's disease (AD) is the most common neurodegenerative disorder. Depositions of amyloid β peptide (Aβ) and tau protein are among the major pathological hallmarks of AD. Aβ and tau burden follows predictable spatial patterns during the progression of AD. Nevertheless, it remains obscure why certain brain regions are more vulnerable than others; to investigate this and dysregulated pathways during AD progression, a mass spectrometry-based proteomics study was performed.<h ...[more]
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