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Proteogenomics of High hyperdiploid childhood acute lymphoblastic leukemia

ABSTRACT: Proteogenomic analysis and genomic profiling, RNA-sequencing, and mass spectrometry-based analysis of High hyperdiploid childhood acute lymphoblastic leukemia.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): B Cell, Bone Marrow, Blood

DISEASE(S): Acute Leukemia

SUBMITTER: Rozbeh Jafari

LAB HEAD: Janne Lehtiö

PROVIDER: PXD010175 | Pride | 2019-02-25

REPOSITORIES: Pride

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Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia.

Yang Minjun M Vesterlund Mattias M Siavelis Ioannis I Moura-Castro Larissa H LH Castor Anders A Fioretos Thoas T Jafari Rozbeh R Lilljebjörn Henrik H Odom Duncan T DT Olsson Linda L Ravi Naveen N Woodward Eleanor L EL Harewood Louise L Lehtiö Janne J Paulsson Kajsa K

Nature communications 20190403 1

Hyperdiploidy, i.e. gain of whole chromosomes, is one of the most common genetic features of childhood acute lymphoblastic leukemia (ALL), but its pathogenetic impact is poorly understood. Here, we report a proteogenomic analysis on matched datasets from genomic profiling, RNA-sequencing, and mass spectrometry-based analysis of >8,000 genes and proteins as well as Hi-C of primary patient samples from hyperdiploid and ETV6/RUNX1-positive pediatric ALL. We show that CTCF and cohesin, which are mas ...[more]

PMID: 30944321

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