Dataset Information

Proteomic landscape of cholangiocarcinomas reveals 3 different subgroups according to their localization and the underlying non-tumor liver

ABSTRACT: Cholangiocarcinomas (CC) define a heterogeneous entity based upon their anatomic localization along the biliary tree and, for those developing in the liver (iCC), depending on the aspect of non tumoral liver (cirrhosis or not). Gene expression analysis of iCC revealed 2 main subgroups (inflammatory and proliferative). The aim of the study was to address the heterogeneity of CC by comparing their protein expression using a global quantitative proteomic approach.

INSTRUMENT(S): Orbitrap Fusion ETD

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Liver

DISEASE(S): Cholangiocarcinoma

SUBMITTER: Thibaut LEGER

LAB HEAD: Valérie Paradis

PROVIDER: PXD010294 | Pride | 2018-12-11

REPOSITORIES: Pride

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Publications

Proteomic Landscape of Cholangiocarcinomas Reveals Three Different Subgroups According to Their Localization and the Aspect of Non-Tumor Liver.

Le Faouder Julie J Gigante Elia E Léger Thibaut T Albuquerque Miguel M Beaufrère Aurélie A Soubrane Olivier O Dokmak Safi S Camadro Jean-Michel JM Cros Jérôme J Paradis Valérie V

Proteomics. Clinical applications 20181219 1

<h4>Purpose</h4>Cholangiocarcinomas (CCs) define a heterogeneous entity based upon their anatomic localization (intra versus extrahepatic) and, for the intrahepatic CCs, the aspect of background liver (normal versus cirrhosis). The aim of the study was to characterize the molecular heterogeneity of CCs by a global proteomic approach.<h4>Experimental design</h4>Thirty-three tumor samples from 17 intrahepatic CCs (iCC) (9 developed on normal (iCC<sub>N</sub> ) and 8 developed in cirrhotic liver (i ...[more]

PMID: 30520266

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Dataset Information

Proteomic landscape of cholangiocarcinomas reveals 3 different subgroups according to their localization and the underlying non-tumor liver

Publications

Proteomic Landscape of Cholangiocarcinomas Reveals Three Different Subgroups According to Their Localization and the Aspect of Non-Tumor Liver.

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