Gene expression profiling of tumor stroma in human intrahepatic cholangiocarcinoma

ABSTRACT: Intrahepatic cholangiocarcinoma (ICC) is the second most common type of primary cancer in the liver. ICC is an aggressive cancer with poor prognosis and limited therapeutic strategies. The identification of new drug targets and prognostic biomarkers is an important clinical challenge for ICC. The presence of an abundant stroma is a histological hallmark of ICC. Given the well established role of the stromal compartment in the progression of cancer diseases, we hypothesized that relevant biomarkers could be identified by analyzing the stroma of ICC. By combining laser capture microdissection and gene expression profiling we demonstrated that ICC stromal cells exhibit dramatic genomic changes. We identified a signature of 1,073 non-redundant genes that significantly discriminate the tumor st

ORGANISM(S): Homo sapiens

SUBMITTER: Cedric Coulouarn 

PROVIDER: E-GEOD-45001 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress