Ontology highlight
ABSTRACT:
INSTRUMENT(S): maXis
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Monocyte, Blood, Macrophage
DISEASE(S): Influenza
SUBMITTER: Momar Ndao
LAB HEAD: Brian J. Ward
PROVIDER: PXD010519 | Pride | 2019-05-28
REPOSITORIES: Pride
Makarkov Alexander I AI Golizeh Makan M Ruiz-Lancheros Elizabeth E Gopal Angelica A AA Costas-Cancelas Ian N IN Chierzi Sabrina S Pillet Stephane S Charland Nathalie N Landry Nathalie N Rouiller Isabelle I Wiseman Paul W PW Ndao Momar M Ward Brian J BJ
NPJ vaccines 20190515
A growing body of evidence supports the importance of T cell responses to protect against severe influenza, promote viral clearance, and ensure long-term immunity. Plant-derived virus-like particle (VLP) vaccines bearing influenza hemagglutinin (HA) have been shown to elicit strong humoral and CD4<sup>+</sup> T cell responses in both pre-clinical and clinical studies. To better understand the immunogenicity of these vaccines, we tracked the intracellular fate of a model HA (A/California/07/2009 ...[more]