Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Bos Taurus (bovine) Homo Sapiens (human) Influenza A Virus (a/california/07-00002/2009(h1n1))
TISSUE(S): B Cell, Dendritic Cell, Blood
DISEASE(S): Influenza
SUBMITTER: Antonino Cassotta
LAB HEAD: Federica Sallusto
PROVIDER: PXD018151 | Pride | 2020-06-29
REPOSITORIES: Pride
The Journal of experimental medicine 20201001 10
The importance of CD4+ T helper (Th) cells is well appreciated in view of their essential role in the elicitation of antibody and cytotoxic T cell responses. However, the mechanisms that determine the selection of immunodominant epitopes within complex protein antigens remain elusive. Here, we used ex vivo stimulation of memory T cells and screening of naive and memory T cell libraries, combined with T cell cloning and TCR sequencing, to dissect the human naive and memory CD4+ T cell repertoire ...[more]