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Proteomic changes in liver tissue of Rat (Rattus norvegicus) following formalin exposure

ABSTRACT: Formaldehyde (HCHO) is the simplest form of aldehyde and it is naturally present in a wide range of resources. In spite of its cosmopolitan presence, formaldehyde can have deleterious health effects at higher concentrations like leukemia. However, most of the studies carried out so far have focused on the effect of formaldehyde exposure through inhalation and not much has been studied on the its exposure through food. In this context, the present study was carried out to investigate the effect of formaldehyde exposure through drinking water on the liver proteome of rat which would not only be helpful in assessing the impact of formaldehyde on health of organisms but also would be helpful in understanding the mechanism of detoxification.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Liver

SUBMITTER: Bimal Mohanty

LAB HEAD: Bimal Prasanna Mohanty

PROVIDER: PXD010534 | Pride | 2020-01-07

REPOSITORIES: Pride

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Proteomic and transcriptomic changes in rat liver following oral feeding of formaldehyde.

Mohanty Bimal Prasanna BP Mahanty Arabinda A Mitra Tandrima T Mohanty Sasmita S Naik Ajit Kumar AK Parija Subas Chandra SC

Chemosphere 20191209

Formaldehyde (FA), a ubiquitous volatile organic compound present in a wide range of resources, is a hazardous chemical and human carcinogen. Contamination of FA in food, especially perishable commodities like fish and meat, is a major source of exposure, although it is not recommended for use in food and food products owing to its carcinogenicity. Effects of oral feeding of FA have been studied by evaluating general health, haematology and clinical chemistry in rat. Recent studies have shown th ...[more]

PMID: 31855752

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