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Quantitative proteomic profiling of brain in Alzheimer’s disease

ABSTRACT: Alzheimer's disease (AD) is the most prevalent form of dementia and the number of AD patients is expected to increase as human life expectancy improves. The deposition of β-amyloid protein (Aβ) in the extracellular matrix and neurofibrillary tangles intracellularly are pathologic hallmarks. Since the precise pathophysiology of AD has not been clearly elucidated yet, effective treatment is not available. Thus the development of valid AD biomarkers is imperative for early diagnosis and for monitoring disease progression and therapeutic responses.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

SUBMITTER: Akhilesh Pandey

LAB HEAD: Akhilesh Pandey, M.D, Ph.D.

PROVIDER: PXD010560 | Pride | 2022-04-01

REPOSITORIES: Pride

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Publications

Quantitative proteomic analysis of the frontal cortex in Alzheimer's disease.

Sathe Gajanan G Albert Marilyn M Darrow Jacqueline J Saito Atsushi A Troncoso Juan J Pandey Akhilesh A Moghekar Abhay A

Journal of neurochemistry 20200722 6

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by intracellular formation of neurofibrillary tangles and extracellular deposition of β-amyloid protein (Aβ) in the extracellular matrix. The pathogenesis of AD has not yet been fully elucidated and little is known about global alterations in the brain proteome that are related to AD. To identify and quantify such AD-related changes in the brain, we employed a tandem mass tags approach coupled to high-resolution mass s ...[more]

PMID: 32614981

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Molecular alterations elicited by chronic exposure to cigarette smoke in oral keratinocytes

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