Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Type B Pancreatic Cell, Endocrine Pancreas
DISEASE(S): Disease Free
SUBMITTER: Nicholas Woods
LAB HEAD: Nicholas T. Woods
PROVIDER: PXD010589 | Pride | 2019-07-25
REPOSITORIES: Pride
Lagundžin Dragana D Hu Wen-Feng WF Law Henry C H HCH Krieger Kimiko L KL Qiao Fangfang F Clement Emalie J EJ Drincic Andjela T AT Nedić Olgica O Naldrett Michael J MJ Alvarez Sophie S Woods Nicholas T NT
PloS one 20190828 8
Hyperinsulinemia affects 72% of Fanconi anemia (FA) patients and an additional 25% experience lowered glucose tolerance or frank diabetes. The underlying molecular mechanisms contributing to the dysfunction of FA pancreas β cells is unknown. Therefore, we sought to evaluate the functional role of FANCA, the most commonly mutated gene in FA, in glucose-stimulated insulin secretion (GSIS). This study reveals that FANCA or FANCB knockdown impairs GSIS in human pancreas β cell line EndoC-βH3. To ide ...[more]