Proteomics

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PLASMA PROTEOMIC ANALYSIS OF RARE BMI-DISCORDANT MONOZYGOTIC TWIN PAIRS

ABSTRACT: The aim of the current study is to establish the effect of excess body wiehgt and liver fat on plasma proteomic profile without interference from genetic variation. Label-free proteomics (HDMSE) was performed on plasma samples of young healthy monozygotic twins who were discordant for BMI. the twins were further subdivided into groups of liver fat discordant and liver fat concordant to see the efefct fo liver fat on plasma proteomic signature.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma, Blood

SUBMITTER: Sakari Joenväärä  

LAB HEAD: Risto Renkonen

PROVIDER: PXD010691 | Pride | 2019-02-01

REPOSITORIES: Pride

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Publications

Plasma Proteomics Analysis Reveals Dysregulation of Complement Proteins and Inflammation in Acquired Obesity-A Study on Rare BMI-Discordant Monozygotic Twin Pairs.

Sahebekhtiari Navid N   Saraswat Mayank M   Joenväärä Sakari S   Jokinen Riikka R   Lovric Alen A   Kaye Sanna S   Mardinoglu Adil A   Rissanen Aila A   Kaprio Jaakko J   Renkonen Risto R   Pietiläinen Kirsi H KH  

Proteomics. Clinical applications 20190205 4

<h4>Purpose</h4>The purpose of this study is to elucidate the effect of excess body weight and liver fat on the plasma proteome without interference from genetic variation.<h4>Experimental design</h4>The effect of excess body weight is assessed in young, healthy monozygotic twins from pairs discordant for body mass index (intrapair difference (Δ) in BMI > 3 kg m<sup>-2</sup> , n = 26) with untargeted LC-MS proteomics quantification. The effect of liver fat is interrogated via subgroup analysis o  ...[more]

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