Mutant PP2A interactome
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion ETD
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Cell Culture
SUBMITTER: 
Alex Kentsis
LAB HEAD: Alex Kentsis
PROVIDER: PXD010709 | Pride | 2020-06-09
REPOSITORIES: Pride
Publications
A Cancer-Associated Missense Mutation in PP2A-Aα Increases Centrosome Clustering during Mitosis.
Antao Noelle V NV Marcet-Ortega Marina M Cifani Paolo P Kentsis Alex A Foley Emily A EA
iScience 20190717
Whole-genome doubling (WGD) is common early in tumorigenesis. WGD doubles ploidy and centrosome number. In the ensuing mitoses, excess centrosomes form a multipolar spindle, resulting in a lethal multipolar cell division. To survive, cells must cluster centrosomes to allow bipolar cell division. Cancer cells are often more proficient at centrosome clustering than untransformed cells, but the mechanism behind increased clustering ability is not well understood. Heterozygous missense mutations in ...[more]
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