Proteomics

Dataset Information

1

Mutant PP2A interactome


ABSTRACT: Affinity enrichment of ligand to mutant and wild-type PP2A protein

INSTRUMENT(S): Orbitrap Fusion ETD

ORGANISM(S): Homo sapiens  

TISSUE(S): Cell Culture

DISEASE(S): Not Available

SUBMITTER: Alex Kentsis  

LAB HEAD: Alex Kentsis

PROVIDER: PXD010709 | Pride | 2020-06-09

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
160411_Foley_blank01.raw Raw
160411_Foley_blank02.raw Raw
160411_Foley_sample#10.raw Raw
160411_Foley_sample#11.raw Raw
160411_Foley_sample#12.raw Raw
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Publications

A Cancer-Associated Missense Mutation in PP2A-Aα Increases Centrosome Clustering during Mitosis.

Antao Noelle V NV   Marcet-Ortega Marina M   Cifani Paolo P   Kentsis Alex A   Foley Emily A EA  

iScience 20190717


Whole-genome doubling (WGD) is common early in tumorigenesis. WGD doubles ploidy and centrosome number. In the ensuing mitoses, excess centrosomes form a multipolar spindle, resulting in a lethal multipolar cell division. To survive, cells must cluster centrosomes to allow bipolar cell division. Cancer cells are often more proficient at centrosome clustering than untransformed cells, but the mechanism behind increased clustering ability is not well understood. Heterozygous missense mutations in  ...[more]

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