Proteomics

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Quantitative proteome analysis of Enterococcus faecalis SK460 during planktonic and biofilm stages

ABSTRACT: Enterococcus faecalis is a major nosocomial pathogen frequently isolated from non- healing wound infections. The major factor responsible for the virulence and establishment of infection is its ability to form robust biofilm. This renders the recalcitrant nature of Enterococci towards the current treatment strategies. In the present study, the quantitative proteomic approach is carried out to elucidate the protein expression levels in E. faecalis at planktonic and biofilm stages. This will help to identify biofilm associated pathways in E. faecalis which inturn can be considered as novel targets for biofilm inhibition.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Enterococcus Faecalis (streptococcus Faecalis)

SUBMITTER: MAHESH CHANDRAN V R  

LAB HEAD: Dr.Sabu Thomas

PROVIDER: PXD010770 | Pride | 2019-07-12

REPOSITORIES: Pride

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Decoding the proteomic changes involved in the biofilm formation of Enterococcus faecalis SK460 to elucidate potential biofilm determinants.

Suryaletha Karthika K   Narendrakumar Lekshmi L   John Joby J   Radhakrishnan Megha Periyappilly MP   George Sanil S   Thomas Sabu S  

BMC microbiology 20190628 1

<h4>Background</h4>Enterococcus faecalis is a major clinically relevant nosocomial bacterial pathogen frequently isolated from polymicrobial infections. The biofilm forming ability of E. faecalis attributes a key role in its virulence and drug resistance. Biofilm cells are phenotypically and metabolically different from their planktonic counterparts and many aspects involved in E. faecalis biofilm formation are yet to be elucidated. The strain E. faecalis SK460 used in the present study is esp (  ...[more]

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