Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Prostate Gland, Cell Culture
DISEASE(S): Prostate Adenocarcinoma
SUBMITTER: Ignacio Ortea
LAB HEAD: Ignacio Ortea
PROVIDER: PXD010993 | Pride | 2019-01-14
REPOSITORIES: Pride
Journal of proteomics 20181025
Galiellalactone (GL) is a fungal metabolite that presents antitumor and antiinflammatory activities in vitro and in vivo. Previous studies have shown that GL targets NF-κB and STAT3 pathways and induces G<sub>2</sub>/M cell cycle arrest in androgen-insensitive prostate cancer cells. In this study, we show that GL-induced cell cycle arrest is independent of the NF-κB and STAT3 pathways in DU145 and PC-3 cells, and also that GL did not affect cell cycling in androgen-sensitive prostate cancer cell ...[more]