Proteomics

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Proteome profiling in APP/PS1 mice brain and modulation by tocotrienol-rich fraction

ABSTRACT: This study examined the proteome profile in the hippocampus, medial prefrontal cortex, and striatum of APPswe/PS1dE9 transgenic mice (APP/PS1) model of Alzheimer’s disease compared to wild-type mice. The effect of tocotrienol-rich fraction (TRF), a mixture of vitamin E analogs derived from palm oil supplementation on the proteome profile of APP/PS1 mice hippocampus, medial prefrontal cortex, and striatum was also investigated. The analysis was performed using ultrahigh-performance liquid chromatography coupled with Q Exactive HF Orbitrap mass spectrometry. This study was in hoped to understand the mechanisms of Alzheimer’s disease at proteome level, and pre-emptive activity of TRF to combat the disease.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Hamizah Shahirah Hamezah  

LAB HEAD: Ikuo Tooyama

PROVIDER: PXD011068 | Pride | 2019-12-06

REPOSITORIES: Pride

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Publications

Modulation of Proteome Profile in AβPP/PS1 Mice Hippocampus, Medial Prefrontal Cortex, and Striatum by Palm Oil Derived Tocotrienol-Rich Fraction.

Hamezah Hamizah Shahirah HS   Durani Lina Wati LW   Yanagisawa Daijiro D   Ibrahim Nor Faeizah NF   Aizat Wan Mohd WM   Makpol Suzana S   Wan Ngah Wan Zurinah WZ   Damanhuri Hanafi Ahmad HA   Tooyama Ikuo I  

Journal of Alzheimer's disease : JAD 20190101 1

Tocotrienol-rich fraction (TRF) is a mixture of vitamin E analogs derived from palm oil. We previously demonstrated that supplementation with TRF improved cognitive function and modulated amyloid pathology in AβPP/PS1 mice brains. The current study was designed to examine proteomic profiles underlying the therapeutic effect of TRF in the brain. Proteomic analyses were performed on samples of hippocampus, medial prefrontal cortex (mPFC), and striatum using liquid chromatography coupled to Q Exact  ...[more]

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