Dataset Information

Proteome characterization of Spleen during Schistosoma mansoni infection

ABSTRACT: Schistosomiasis is a chronic parasitic disease that affects more that 230 million people worldwide. In the Americas, it caused by the blood flook Schistosoma mansoni. This parasite has a complex life cycle with two intermediary hosts. When infecting mammals, schistosomes cause an intense immune response to the presence of the different stages of the parasite within the host. After maturation of the worms and commencing of the oviposition, some eggs are transported via circulation to the liver, where they elicit an exaggerated inflammatory response in the tissue. This could lead to the formation of granulomas and liver fibrosis and along with this, the developent of hepatosplenomegaly and in the worst scenario could lead to the dead of the patient. In this project, we aim to make a shotgun evaluation of the proteome from splenocytes in a mice model, in order to identify novel molecular signatures associated with the immune respose to the presence of the parasite in the hosts.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Spleen

DISEASE(S): Schistosomiasis

SUBMITTER: William Borges

LAB HEAD: William Castro Borges

PROVIDER: PXD011153 | Pride | 2019-02-13

REPOSITORIES: Pride

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Publications

The Schistosomiasis SpleenOME: Unveiling the Proteomic Landscape of Splenomegaly Using Label-Free Mass Spectrometry.

Cosenza-Contreras Miguel M de Oliveira E Castro Renata Alves RA Mattei Bruno B Campos Jonatan Marques JM Gonçalves Silva Gustavo G de Paiva Nívia Carolina Nogueira NCN de Oliveira Aguiar-Soares Rodrigo Dian RD Carneiro Cláudia Martins CM Afonso Luis Carlos Crocco LCC Castro-Borges William W

Frontiers in immunology 20190122

Schistosomiasis is a neglected parasitic disease that affects millions of people worldwide and is caused by helminth parasites from the genus <i>Schistosoma</i>. When caused by <i>S. mansoni</i>, it is associated with the development of a hepatosplenic disease caused by an intense immune response to the important antigenic contribution of adult worms and to the presence of eggs trapped in liver tissue. Although the importance of the spleen for the establishment of immune pathology is widely acce ...[more]

PMID: 30728824

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			Action	DRS
	Control1.raw	Raw
	Control1.sepr	Other
	Control1.sqt	Other
	Control2.raw	Raw
	Control2.sepr	Other