Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Suspension Culture, Permanent Cell Line Cell
DISEASE(S): Colon Cancer
SUBMITTER: Patrick Murphy
LAB HEAD: Shashi Gujar
PROVIDER: PXD011464 | Pride | 2019-03-05
REPOSITORIES: Pride
Murphy J Patrick JP Yu Qijia Q Konda Prathyusha P Paulo Joao A JA Jedrychowski Mark P MP Kowalewski Daniel J DJ Schuster Heiko H Kim Youra Y Clements Derek D Jain Aditya A Stevanovic Stefan S Gygi Steven P SP Mancias Joseph D JD Gujar Shashi S
Analytical chemistry 20190222 8
MHC-I peptides are intracellular-cleaved peptides, usually 8-11 amino acids in length, which are presented on the cell surface and facilitate CD8<sup>+</sup> T cell responses. Despite the appreciation of CD8<sup>+</sup> T-cell antitumor immune responses toward improvement in patient outcomes, the MHC-I peptide ligands that facilitate the response are poorly described. Along these same lines, although many therapies have been recognized for their ability to reinvigorate antitumor CD8<sup>+</sup> ...[more]