Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Drosophila Melanogaster (fruit Fly)
TISSUE(S): Brain, Gut, Muscle, Thorax, Fat Body
SUBMITTER: Robert Sehlke
LAB HEAD: Linda Partridge
PROVIDER: PXD011589 | Pride | 2021-04-21
REPOSITORIES: Pride
Tain Luke Stephen LS Sehlke Robert R Meilenbrock Ralf Leslie RL Leech Thomas T Paulitz Jonathan J Chokkalingam Manopriya M Nagaraj Nagarjuna N Grönke Sebastian S Fröhlich Jenny J Atanassov Ilian I Mann Matthias M Beyer Andreas A Partridge Linda L
eLife 20210421
Reduced activity of the insulin/IGF signalling network increases health during ageing in multiple species. Diverse and tissue-specific mechanisms drive the health improvement. Here, we performed tissue-specific transcriptional and proteomic profiling of long-lived <i>Drosophila dilp2-3,5</i> mutants, and identified tissue-specific regulation of >3600 transcripts and >3700 proteins. Most expression changes were regulated post-transcriptionally in the fat body, and only in mutants infected with th ...[more]