Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency

ABSTRACT: Using co-immunoprecipitation and mass spectrometry analysis we identify unique FLCN binding partners. The interactions of FLCN with components of the mTOR pathway (mTORC1 and mTORC2) reveal a mechanism of FLCN function during exit from naïve pluripotency.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Embryonic Stem Cell

SUBMITTER: Aaron Robitaille  

LAB HEAD: Hannele Ruohola-Baker

PROVIDER: PXD011736 | Pride | 2019-02-13

REPOSITORIES: Pride