Proteomics

Dataset Information

26

Proteomics of Brain Proteome Revealed Altered Mitochondrial Function in Alzheimer Disease


ABSTRACT: A discovery-driven approach with isobaric tag for relative and absolute quantitation (iTRAQ) and label-free quantitative proteomics was used to profiled the mitochondrial proteome in human brain tissues of healthy and AD individuals.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo sapiens  

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Sunil Adav  

LAB HEAD: Prof Sze S K

PROVIDER: PXD012203 | Pride | 2019-02-01

REPOSITORIES: pride

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Publications

Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimer's disease.

Adav Sunil S SS   Park Jung Eun JE   Sze Siu Kwan SK   Sze Siu Kwan SK  

Molecular brain 20190128 1


Mitochondrial dysfunction is a key feature in both aging and neurodegenerative diseases including Alzheimer's disease (AD), but the molecular signature that distinguishes pathological changes in the AD from healthy aging in the brain mitochondria remain poorly understood. In order to unveil AD specific mitochondrial dysfunctions, this study adopted a discovery-driven approach with isobaric tag for relative and absolute quantitation (iTRAQ) and label-free quantitative proteomics, and profiled the  ...[more]

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