Dataset Information


Quantitative proteomic analysis of hippocampal tissues from mice treated with a CK1δ/ε inhibitor

ABSTRACT: Hippocampal tissues from 3xTg-AD mice treated with a CK1δ/ε inhibitor or vehicle, and non-transgenic mice treated with vehicle, were harvested and processed for proteomic analysis using label-free quantification.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus musculus  

TISSUE(S): Brain

DISEASE(S): Not Available

SUBMITTER: Paula Adler  

LAB HEAD: Daniel Figeys

PROVIDER: PXD012281 | Pride | 2019-07-30


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Therapeutic Targeting of Casein Kinase 1δ/ε in an Alzheimer's Disease Mouse Model.

Adler Paula P   Mayne Janice J   Walker Krystal K   Ning Zhibin Z   Figeys Daniel D  

Journal of proteome research 20190806 9

Sleep disturbances and memory impairment are common symptoms of Alzheimer's disease (AD). Given that the circadian clock regulates sleep, hippocampal function, and neurodegeneration, it represents a therapeutic target against AD. Casein kinase 1δ/ε (CK1δ/ε) are clock regulators and overexpressed in AD brains, making them viable targets to improve sleep and cognition. In this study, we evaluated the therapeutic potential of a small molecule CK1δ/ε inhibitor (PF-670462) in a triple transgenic mous  ...[more]

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