Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion ETD
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell, Stem Cell, Cell Culture
DISEASE(S): Brain Cancer
SUBMITTER: Torsten Mueller
LAB HEAD: Marcel Kool
PROVIDER: PXD012318 | Pride | 2019-07-08
REPOSITORIES: Pride
Hübner Jens-Martin JM Müller Torsten T Papageorgiou Dimitris N DN Mauermann Monika M Krijgsveld Jeroen J Russell Robert B RB Russell Robert B RB Ellison David W DW Pfister Stefan M SM Pajtler Kristian W KW Kool Marcel M
Neuro-oncology 20190701 7
<h4>Background</h4>Posterior fossa A (PFA) ependymomas are one of 9 molecular groups of ependymoma. PFA tumors are mainly diagnosed in infants and young children, show a poor prognosis, and are characterized by a lack of the repressive histone H3 lysine 27 trimethylation (H3K27me3) mark. Recently, we reported overexpression of chromosome X open reading frame 67 (CXorf67) as a hallmark of PFA ependymoma and showed that CXorf67 can interact with enhancer of zeste homolog 2 (EZH2), thereby inhibiti ...[more]