Phosphorylation of CPSF6 RS-like domain
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Kidney
SUBMITTER: 
Parmit Singh
LAB HEAD: Alan N. Engelman
PROVIDER: PXD012713 | Pride | 2019-04-01
REPOSITORIES: Pride
Publications
Differential role for phosphorylation in alternative polyadenylation function versus nuclear import of SR-like protein CPSF6.
Jang Sooin S Cook Nicola J NJ Pye Valerie E VE Bedwell Gregory J GJ Dudek Amanda M AM Singh Parmit K PK Cherepanov Peter P Engelman Alan N AN
Nucleic acids research 20190501 9
Cleavage factor I mammalian (CFIm) complex, composed of cleavage and polyadenylation specificity factor 5 (CPSF5) and serine/arginine-like protein CPSF6, regulates alternative polyadenylation (APA). Loss of CFIm function results in proximal polyadenylation site usage, shortening mRNA 3' untranslated regions (UTRs). Although CPSF6 plays additional roles in human disease, its nuclear translocation mechanism remains unresolved. Two β-karyopherins, transportin (TNPO) 1 and TNPO3, can bind CPSF6 in v ...[more]
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