Ontology highlight
ABSTRACT:
INSTRUMENT(S): impact II
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Neutrophil
SUBMITTER: Laura Dagley
LAB HEAD: Fernando Souza-Fonseca-Guimaraes
PROVIDER: PXD012794 | Pride | 2020-02-19
REPOSITORIES: Pride
Louis Cynthia C Souza-Fonseca-Guimaraes Fernando F Yang Yuyan Y D'Silva Damian D Kratina Tobias T Dagley Laura L Hediyeh-Zadeh Soroor S Rautela Jai J Masters Seth Lucian SL Davis Melissa J MJ Babon Jeffrey J JJ Ciric Bogoljub B Vivier Eric E Alexander Warren S WS Huntington Nicholas D ND Wicks Ian P IP
The Journal of experimental medicine 20200501 5
Despite increasing recognition of the importance of GM-CSF in autoimmune disease, it remains unclear how GM-CSF is regulated at sites of tissue inflammation. Using GM-CSF fate reporter mice, we show that synovial NK cells produce GM-CSF in autoantibody-mediated inflammatory arthritis. Synovial NK cells promote a neutrophilic inflammatory cell infiltrate, and persistent arthritis, via GM-CSF production, as deletion of NK cells, or specific ablation of GM-CSF production in NK cells, abrogated dise ...[more]