Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): B Cell, Cell Culture
SUBMITTER: Michael Ghosh
LAB HEAD: Stefan Stevanovic
PROVIDER: PXD012797 | Pride | 2020-01-15
REPOSITORIES: Pride
Molecular & cellular proteomics : MCP 20200114 3
For more than two decades naturally presented, human leukocyte antigen (HLA)-restricted peptides (immunopeptidome) have been eluted and sequenced using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Since, identified disease-associated HLA ligands have been characterized and evaluated as potential active substances. Treatments based on HLA-presented peptides have shown promising results in clinical application as personalized T cell-based immunotherapy. Peptide vaccination cocktails ...[more]