Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Fibroblast
SUBMITTER: Justine Marsolier
LAB HEAD: Jonathan WEITZMAN
PROVIDER: PXD012895 | Pride | 2019-11-13
REPOSITORIES: Pride
Marsolier Justine J Perichon Martine M Weitzman Jonathan B JB Medjkane Souhila S
Communications biology 20190430
Metabolic reprogramming is an important feature of host-pathogen interactions and a hallmark of tumorigenesis. The intracellular apicomplexa parasite <i>Theileria</i> induces a Warburg-like effect in host leukocytes by hijacking signaling machineries, epigenetic regulators and transcriptional programs to create a transformed cell state. The molecular mechanisms underlying host cell transformation are unclear. Here we show that a parasite-encoded prolyl-isomerase, TaPin1, stabilizes host pyruvate ...[more]